4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide

Name	3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE
Synonyms	DHBA DHBA HYDROBROMIDE 4-(aminomethyl)benzene-1,2-diol (3,4-dihydroxyphenyl)methanaminium 4-(AMINOMETHYL)CATECHOL HYDROBROMIDE 3,4-DIHYDROXYBENZYLAMINE HYDROBROMIDE 4-(aminomethyl)pyrocatechol hydrobromide 3,4-Dihydroxybenzylamine·hydrogen bromide 4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide 4-(Aminomethyl)catechol hydrobromide, DHBA hydrobromide
CAS	16290-26-9
EINECS	240-382-8
InChI	InChI=1/C7H9NO2.BrH/c8-4-5-1-2-6(9)7(10)3-5;/h1-3,9-10H,4,8H2;1H

Molecular Formula	C7H10BrNO2
Molar Mass	220.06
Melting Point	184-186°C(lit.)
Boling Point	357.4°C at 760 mmHg
Flash Point	170°C
Vapor Presure	1.32E-05mmHg at 25°C
Appearance	Crystalline Powder
Color	Light beige
BRN	4002646
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	Hygroscopic
Physical and Chemical Properties	Sensitivity: hydrogen WGK Germany:3

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	29222900

biological activity	3,4-Dihydroxybenzylamine hydrate (NSC 263475 hydrate) is a structurally modified dopamine analog cytotoxicant, inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrochloride showed different growth inhibitory activity in melanoma cell lines with different degrees of tyrosinase activity.
Cell Line:	Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines
Concentration:	1 μM-10 mM
Incubation Time:	48 hours
Result:	Inhibited melanoma cell Lines growth. Exhibited increased life-span of 44%,46%, 70% and 50% for 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg, respectively.
Animal Model:	C57BL/6 mice with B6D2F1 cells
Dosage:	200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg
Administration:	Intraperitoneal injection